One of the reasons that the tragic end of George and Lennie’s friendship has such a profound impact is that one senses that the friends have, by the end of the novella, lost a dream larger than themselves. The farm on which George and Lennie plan to live—a place that no one ever reaches—has a magnetic quality, as Crooks points out. After hearing a description of only a few sentences, Candy is completely drawn in by its magic. Crooks has witnessed countless men fall under the same silly spell, and still he cannot help but ask Lennie if he can have a patch of garden to hoe there. The men in the novel desire to come together in a way that would allow them to be like brothers to one another. That is, they want to live with one another’s best interests in mind, to protect each other, and to know that there is someone in the world dedicated to protecting them. Given the harsh, lonely conditions under which these men live, it should come as no surprise that they idealize friendships between men in such a way.
Ultimately, however, the world is too harsh and predatory a place to sustain such relationships. Lennie and George, who come closest to achieving this ideal of brotherhood, are forced to separate tragically. With this, a rare friendship vanishes, but the rest of the world—represented by Curley and Carlson, who watch George stumble away with grief from his friend’s dead body—fails to acknowledge or appreciate it.